differentials for bullosis diabeticorum comprise bacterial and fungal infections, metabolic and autoimmune disorders, mechanical injuries, variants of dermatitis and papulosquamous rashes. Key words: Bullae, blister, vesicle, lower extremity, podiatry, dermatology

The differential diagnosis must be made with epidermolysis bullosa, pemphigus, bullous pemphigoid, burns, erysipelas, arthropod bites and others. The histopathology exam is not typical. The dermatologist should suspect of the disease in long-term diabetic patients of with blisters in acral locations without marked inflammation

Clinically important is the association of bullosis diabeticorum with diabetic retinopathy, nephropathy and polyneuropathy. There is no association with insulin dependence. Differential diagnosis. This section has been translated automatically. Other blistering dermatoses, especially porphyria cutanea tarda; 2012-06-28 differentials for bullosis diabeticorum comprise bacterial and fungal infections, metabolic and autoimmune disorders, mechanical injuries, variants of dermatitis and papulosquamous rashes.

Bullosis diabeticorum differential diagnosis

It usually arises in those with longstanding diabetes, and affects 0.5% of the diabetic population in the U.S. in a 2:1 male-to-female ratio.1 It erupts spontaneously mainly on acral surfaces of the upper and lower extremities, but may also involve the trunk. Bullosis diabeticorum is a distinct, spontaneous, noninflammatory, and blistering condition of acral skin that is unique to diabetics. The differential diagnosis includes friction bullae, Bullosis diabeticorum associated with osteomyelitis. Tenn Med. 2004 Nov. 97(11):503-4. .

The pathogenesis of diabetic bullae is unclear. These painless bullae may be the first presentation of diabetes, appearing suddenly, commonly on lower limbs.

Bullosis diabeticorum is part of the spectrum of cutaneous manifestations of diabetes mellitus1,2, described by Kramer in 19301 and named bullosis diabeticorum by Cantwell and Martz3. It is a known disease, but quite rare (0,5 to 2% of the diabetic population)4, underdiagnosed in most cases2, and is two times more common in men4,5.

Fung M.A, Murphy M.J, Hoss DM, Berke A, Grant-Kels J.M. The sensivity and specificity of “caterpillar bodies” in the differential diagnosis of subepidermal blistering disorders. Investigations which included skin biopsies confirmed the diagnosis of bullosis diabeticorum. The bullae were treated with hydrotherapy and healed with no complications in 4 weeks. We present this case to illustrate the rare occurrence of diabetic bulla in a diabetic patient especially with poor glycemic control.

Bullosis diabeticorum differential diagnosis

Bullosis diabeticorum is part of the spectrum of cutaneous manifestations of diabetes mellitus1,2, described by Kramer in 19301 and named bullosis diabeticorum by Cantwell and Martz3. It is a known disease, but quite rare (0,5 to 2% of the diabetic population)4, underdiagnosed in most cases2, and is two times more common in men4,5.

3.1 Vesiculobullous rashes; 4 Evaluation. 4.1 Rash Red Flags [1] 5 Management; 6 Bullosis diabeticorum is a rare blister formation locat … We report two cases of patients with diabetes mellitus who developed bullae measuring 2 cm in diameter on the fingers or toes, which could be classified as bullosis diabeticorum after excluding several differential diagnoses that are discussed. Bullosis diabeticorum (BD), also known as diabetic bullae or bullous eruption of diabetes mellitus, is a specific type of skin lesion occurring in patients with diabetes mellitus.

Bullosis diabeticorum is a rare cutaneous complication in those with diabetes mellitus. The condition was first recognized in 1930, and the name coined in 1967. It usually arises in those with longstanding diabetes, and affects 0.5% of the diabetic population in the U.S. in a 2:1 male-to-female ratio. 1 It erupts spontaneously mainly on acral surfaces of the upper and lower extremities, but The distribution and appearance of the bulla led to a clinical diagnosis of bullosis diabeticorum, a rare but likely underdiagnosed condition in patients with diabetes.
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It is a rare disorder, probably underdiagnosed, associated with long-term diabetes mellitus. Its etiology remains unclear. It is characterized by tense blisters, with serous content, recurrent and spontaneous on normal skin especially in the acral regions. Bullous disease of diabetes (bullosis diabeticorum) is a distinct, spontaneous, noninflammatory, blistering condition of acral skin that is unique to patients with diabetes mellitus. Kramer first Diagnosis confirmation –Bullae, clear or hemorrhagic, associated with neuropathy (lack of sensation) over pressure points on the feet.

The differential diagnosis includes friction bullae, bullae due Bullosis diabeticorum (BD) is considered a rare and relatively harmless skin manifestation with tense blisters appearing rapidly and mostly on the feet. Most papers report only a few cases and the Bullosis diabeticorum is part of the spectrum of cutaneous manifestations of diabetes mellitus1,2, described by Kramer in 19301 and named bullosis diabeticorum by Cantwell and Martz3. It is a known disease, but quite rare (0,5 to 2% of the diabetic population)4, underdiagnosed in most cases2, and is two times more common in men4,5.
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Mar 15, 2021 Skin inflammatory (nontumor) - Bullous pemphigoid - most common pathology report | Differential diagnosis | Board review style question #1

The histologic features of bullosis diabeticorum are not very specific. Histology typically reveals a noninflammatory blister with separation in an intraepidermal or subepidermal location.

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We present a case of bullosis diabeticorum. It is a rare disorder, probably underdiagnosed, associated with long-term diabetes mellitus. Its etiology remains unclear. It is characterized by tense blisters, with serous content, recurrent and spontaneous on normal skin especially in the acral regions.

1 Background; 3 Differential Diagnosis. 3.1 Vesiculobullous rashes; 4 Evaluation.